TNS stands for Trapped Neutrophil Syndrome, an hereditary disease where the bone marrow produces neutrophils (white cells) but is unable to effectively release them into the bloodstream.
Affected puppies have an impaired immune system and will eventually die from infections they cannot fight.
Once thought to be rare, it is now believed that the disease goes undiagnosed for several reasons. First, not very many veterinarians know about the disease to look for it.
Second, even when looking, blood counts do not always show lower than normal neutrophil (white blood cell) counts. Finally, because it is an autoimmune-deficiency disease, young puppies present a variety of symptoms depending upon what infections they fall prone to.
Thus many cases are not properly diagnosed and have just been thought to be “fading puppies”.
Making the diagnosis even more difficult is the fact that age of onset varies depending on which infection is involved at the time. Most puppies become ill before leaving the breeder but some do not have symptoms until later. The oldest known survivor was 2 years 8 months. Most affected puppies die or are euthanized by about 4 months of age.
The research now suggests that the gene is widespread throughout the Border Collie breed. TNS cases have been positively diagnosed in Australia, Great Britain, Hungary, the Netherlands, New Zealand, and the United States.
TNS carriers have been identified in lines not related to the Australian and New Zealand lines where the disease was first identified – including 100% ISDS lines. It is autosomal recessive, which means that both parents have to be carriers to produce an affected puppy.
TNS Research Update Report – May 21, 2007
This database contains results as tested by various laboratories from around the world. The current test, developed by Dr. Alan Wilton, is not for the mutation itself but for inheritance of the chromosome carrying the TNS mutation. In the table, CLEAR indicates that the TNS carrying chromosome was not inherited.
It is with great sadness that we acknowledge the passing of Dr. Alan Wilton. This TNS database is dedicated to his memory, who’s undying dedication made it possible for Border Collies to be bred without the possibility of producing puppies with TNS.
All results are individually submitted by the owners of the dogs.
It is now possible to test all Border Collies! Downloadable Forms are available in PDF format.
If you would like your information included on this website, please click here.
(At this time, we are only able to include dogs who have actually been tested, not dogs clear by parentage. Please remember to include your Accession or Lab Number as this validates the reports submitted.)
(By submitting your information, you agree to make the information public and have it published on this website. This information is being provided for personal use only. Any reproduction, in whole or in part, of the data contained herein is expressly forbidden without the written permission of the owner of this database.)Â
(If you are the registered owner of a dog listed on this database and you would like your dog’s information to be removed, please click here.)
Normal/Clear | Carriers | Affecteds | Total Listed |
1845 | 412 | 16 | 2273 |
TNS Pedigrees Pedigree last added June 8, 2007 Pedigrees last updated May 1, 2007
Brazil TNS Test Results
Normal/Clear | Carrier | Affected |
22 | 1 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
April Coast Borders Ranch | Juliana Spezzacatena | RG/SPX/09/06025 | Black Hand Painted | Cassy Hand Painted | November 20, 2009 | Female | 12-7394 | Normal/Clear |
Best In Border Rolex | Camila Junqueira | RG/SPX/09/02269 | Bayshore Avatar Toth | Avatar Flying To Me Bayshore | May 16, 2009 | Male | UNSW_ID 6231 | Normal/Clear |
Best In Border Sweet Semillon | Eduardo Machado | RG/SPX/05/07695 | Clan-Abby NZ Blue Snow Bear | Brisa Trip Animal Friend | November 1, 2005 | Female | UNSW_ID 5396 | Normal/Clear |
Best In Border The Aller Beginning | Eduardo Machado | RG/SPX/08/01067 | Shoreland’s The Golden Rule | Lucky Charm Mationa | February 6, 2008 | Male | 09/9108 | Normal/Clear |
Best In Border West End Girl | Juliana Spezzacatena | RG/SPX/06/04846 | Bayshore’s Believe In Magic | St Thoth Best In Border Lady Macbeth | July 17, 2006 | Female | 12-7396 | Normal/Clear |
Border Aller Make Cookie In Dallas | Eduardo Machado | RG/SCB/09/00029 | Bayshore Avatar Dallas | Br St Thoth Best In Border La Boheme | February 21, 2009 | Male | UNSW_ID 5394 | Normal/Clear |
Border Aller One Man Band | Daniela Paulucci Santos de Moraes | RG/SCB/08/00457 | Grey 223 Dos Pardais | Best In Border Sweet Semillon | August 12, 2008 | Male | 12-10037 | Normal/Clear |
Border Aller One Up Fashion | Eduardo Machado | RG/SCB/08/00464 | Grey 223 Dos Pardais | Best In Border Sweet Semillon | August 12, 2008 | Female | UNSW_ID 5398 | Normal/Clear |
Br St Thoth Best In Border La Boheme | Eduardo Machado | RG/SPX/05/01526 | Bayshore Avatar Toth | Brisa Trip Animal Friend | April 21, 2005 | Female | UNSW_ID 5397 | Normal/Clear |
Extra Maggie do Emporium dos Cćes | Camila Junqueira | RG/SPB/09/00466 | Best In Border Man Of La Mancha | Br St Thoth’s Best In Border Helene | June 19, 2009 | Female | UNSW_ID 6234 | Normal/Clear |
Eyes Of The World Cooper | Anja Dekegel | LOSH 0932254 | Mobella The Fella | Eyes Of The World Yellow Rose | August 19, 2003 | Male | UNSW_ID 5802 | Normal/Clear |
Good Captain da Cabanha da Conquista | Juliana Spezzacatena Martins | RS/SPW/10/36128 | Brusky Bellintani | Chess BR Borderland | February 18, 2010 | Male | 12-5641 | Normal/Clear |
Hanna do Kanove | Ana Paula Ambrozini | RG/SPX/04/06317 | Border do Kanove | Fila de Preton | November 11, 2004 | Female | UNSW_ID 5902 | Normal/Clear |
Hi-Fi Para Emporium Encrenquinha’s | Camila Sakavicius | RG/SPAI/09/02518 | Best In Border Sharm-El-Sheykh | Best In Border Si Mi Chiamano Mimi | May 5, 2009 | Male | 10-302 | Normal/Clear |
JBK My Money Is On The Winner | Eduardo Machado | BR7670 | JBK Show Me The Money | Shoreland’s Rock ‘N’ Roll Fantasy | September 1, 2012 | Female | 13-3418 | Normal/Clear |
Johnnie Walker do Emporium dos Cćes | Camila Junqueira | RG/SPB/09/00037 | Fera dos Pardais | Vany 253 dos Pardais | January 11, 2009 | Male | UNSW_ID 6233 | Normal/Clear |
Kate J. C. C. | Juliana Spezzacatena | RG/SPG/08/01183 | Trick Treuwachter | Deedee 164 Encruzilhada Do Sul | August 14, 2008 | Female | 12-7395 | Normal/Clear |
Lord Manske J Mary | Joćo Carlos Carvalho | RG/SPZ/11/00454 | Shoreland’s Mocha Latte | Lord Manske Lynn | August 6, 2011 | Female | 12-10043 | Normal/Clear |
Lucky Charm Cartita | Ana Paula Ambrozini | BR4494 | Clan-Abby NZ Kiwi Robbie | Gypsy-Queen de Mafalda’s | September 14, 2008 | Female | UNSW_ID 5901 | Normal/Clear |
Lucky Charm Iracema | Eduardo Machado | KCC 337126 | Clan-Abby NZ Kiwi Robbie | Gypsy Queen De Mafalada’s | September 14, 2008 | Female | UNSW_ID 5395 | Carrier |
R’Petra 367 Dos Pardais | André L. C. da Silva | RG/SPX/09/01623 | Best In Border Man Of La Mancha | Angra Dos Pardais | April 13, 2009 | Female | 10-304 | Normal/Clear |
Shut Up Pb do Emporium dos Caes | Ana Paula Ambrozini | RG/SPB/10/00980 | Zico do Sol do Sul | Hanna do Kanove | October 18, 2010 | Female | 10-9697 | Normal/Clear |
Sukita Baby Encrenquinha’s | Ana Paula Ambrozini | RG/SPAI/10/00739 | Best In Border Sharm-El-Sheykh | Best In Border Si Mi Chiamano Mimi | January 8, 2010 | Female | UNSW_ID 6170 | Normal/Clear |
Vanny 253 dos Pardais | Camila Sakavicius | RG/SPX/07/00394 | Red-Dawn Eric | Cam Do Kanove | February 19, 2007 | Female | 10-3547 | Normal/Clear |
Bulgaria TNS Test Results
Normal/Clear | Carrier | Affected |
1 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Caster From Cranberry Cottage | Plamen Kirov | 981100002368516 | Azzuro From Carolyn’s Home | Aymara From Cranberry Cottage | April 18, 2010 | Male | 12-6711 | Normal/Clear |
Hong Kong TNS Test Results
Normal/Clear | Carrier | Affected |
4 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Coolby | Cat Mok | B-12776 | Ken | Apple | December 8, 2003 | Female | UNSW_ID 3308 | Normal/Clear |
Coolbyfans Panda | Cat Mok | B-12831 | Jacky | Coolby | November 30, 2005 | Male | UNSW_ID 3309 | Normal/Clear |
Great Lady | Cat Mok | B-12775 | Ben | Rose | September 15, 2003 | Female | UNSW_ID 3311 | Normal/Clear |
J.J. | Cat Mok | B-12711 | Ben | Coolby | April 28, 2005 | Male | UNSW_ID 3310 | Normal/Clear |
Luxembourg TNS Test Results
Normal/Clear | Carrier | Affected |
1 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Grappa’s Blue Magic At Wendigo’s Wind | Paulus Monique | LOL 22746 | Merlins Blue Magic From Carolyn’s Home | Chilled Out At Wendigo’s Wind | October 6, 2008 | Female | 12-990 | Normal/Clear |
Romania TNS Test Results
Normal/Clear | Carrier | Affected |
1 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Eyes Of The World Jarunee | Paul Schevenels | LOSH 1082836 | Eyes Of The World Excalibur At Bilyara | Eyes Of The World Bony Be Good | May 8, 2010 | Female | UNSW_ID 5947 | Normal/Clear |
Serbia TNS Test Results
Normal/Clear | Carrier | Affected |
1 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Bordermania All Hell Break’s Loose | Aleksandra Vlascic & Judit Novak | Met Bord Coll 1713/09 | Pikkupaimenen Great Pretender At Locheil | Nice Of You To Come Bye Red Rose | January 24, 2009 | Male | UNSW_ID 4740 | Normal/Clear |
Slovakia TNS Test Results
Normal/Clear | Carrier | Affected |
4 | 1 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
A Little Casey Shadow Flame | Ing. Laura Blublová | ? | Lightspeed Aragorn | Heavenly Casey Black Chevers | April 9, 2008 | Female | UNSW_ID 4417 | Normal/Clear |
Baby z Jablonovho Dvora | Slavka Vecerova | SPKP 92/08 | Ghent Bohemia Alke | Baby Te Pito O Te Henua | June 15, 2004 | Female | 09-9662 | Normal/Clear |
Blacksheep Taff | Ing. Laura Blublová | ? | Killiebrae Laddie | Susie | October 20, 2007 | Male | 11-8428 | Normal/Clear |
Heavenly Casey Black Chevers | Ing. Laura Blublová | ? | Brains´n Beauty Monty Python On My Own | Day by Day Black Chevers | October 16, 2005 | Female | 07-2846 | Carrier |
Windy Bohemia Alke | Lucia Olahova | SPKP 173 | Wendevick Zephyr | forth Bohemia Alke | May 11, 2006 | Female | UNSW_ID 4415 | Normal/Clear |
Sweden TNS Test Results
Normal/Clear | Carrier | Affected |
1 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Beesting Dream Machine | Christina Groenvall | REGV 1679/2006 | Meleswood Rather Special | Beesting Starlight | June 6, 2006 | Male | UNSW_ID 3857 | Normal/Clear |
Switzerland TNS Test Results
Normal/Clear | Carrier | Affected |
1 | 0 | 0 |
Registered Name | Owners Name | Registration Number | Sire | Dam | Date of Birth | Gender | Lab Number | Assessment |
Sweep (Groeneweg) | Nadine Steurer | SHSB 673494 ISDS 295924 | Glen (v.d. Zweep) | Maid (Groeneweg) | August 25, 2007 | Male | DV11083879 | Normal/Clear |