TNS DNA Border Collie
Test
Results
__________________________________________________________________________
TNS stands for Trapped Neutrophil Syndrome, an hereditary disease where
the bone marrow produces neutrophils (white cells) but is unable to effectively
release them into the bloodstream. Affected puppies have an impaired immune
system and will eventually die from infections they cannot fight.
Once thought to be rare, it is now believed that the disease goes undiagnosed
for several reasons. First, not very many veterinarians know about
the disease to look for it. Second, even when looking, blood counts
do not always show lower than normal neutrophil (white blood cell) counts.
Finally, because it is an autoimmune-deficiency disease, young puppies present
a variety of symptoms depending upon what infections they fall prone to.
Thus many cases are not properly diagnosed and have just been thought to
be "fading puppies".
Making the diagnosis even more difficult is the fact that age of onset varies
depending on which infection is involved at the time. Most puppies
become ill before leaving the breeder but some do not have symptoms until
later. The oldest known survivor was 2 years 8 months. Most affected
puppies die or are euthanized by about 4 months of age.
The research now suggests that the gene is widespread throughout the Border
Collie breed.
TNS cases have been positively diagnosed in Australia, Great Britain,
Hungary,
the Netherlands, New Zealand, and the United States.
TNS carriers have been identified in lines not related to the Australian
and New Zealand lines
where the disease was first identified - including 100% ISDS lines.
It is autosomal recessive, which means that both parents have to be
carriers to produce an affected puppy.
TNS
Research Update Report - May 21, 2007
___________________________________________________________________________
This database contains results as tested by Dr Alan Wilton at the University
Of New South Wales.
The current test
is not for the mutation itself but for inheritance of the chromosome carrying
the TNS
mutation. In the table, CLEAR indicates that the TNS carrying chromosome
was not inherited.
All results are individually submitted by the owners of the dogs.
It is now possible to test all Border
Collies!
Downloadable
Forms are available from this website in pdf format.
If you would like more information on TNS,
or would like to have your dog tested and need to request collection kits,
please contact
Dr Alan Wilton.
If you would like your information included on this website, please click on the
link, fill in the information, and press the "Submit" button at the bottom of the page.
(At this time, we are only able to include dogs who have actually been tested, not dogs clear by parentage. Please remember to include your Accession or Lab Number as this validates the reports submitted.)
(By submitting your information, you agree to make the information
public and have it published on this website. This information is
being provided for personal use only. Any reproduction, in whole or
in part, of the data contained herein is expressly forbidden
without the written permission of the owner of this database.)
(If you are the registered owner of a dog listed on this database
and you would like your dog's information to be removed, please
click
here.)
Table of TNS Testing Results by Country as of January 26, 2008
Country |
No. Tested |
TNS clears |
TNS carriers |
TNS affected |
Austria |
45 |
32 |
12 |
1 |
Belgium |
150 |
107 |
42 |
1 |
Czech |
14 |
13 |
1 |
0 |
Denmark |
52 |
47 |
5 |
0 |
Finland |
93 |
70 |
23 |
0 |
France |
7 |
5 |
2 |
0 |
Germany |
228 |
181 |
47 |
0 |
Hungary |
28 |
21 |
7 |
0 |
Ireland |
8 |
7 |
1 |
0 |
Italy |
7 |
6 |
1 |
0 |
Luxemburg |
2 |
1 |
1 |
0 |
Netherlands |
132 |
90 |
41 |
1 |
Spain |
7 |
5 |
2 |
0 |
UK |
714 |
548 |
163 |
3 |
Others |
8 |
8 |
0 |
0 |
|
|
|
|
|
Europe Total |
1248 |
954 |
289 |
5 |
ISDS only |
78 |
70 |
8 |
0 |
|
|
|
|
|
USA |
280 |
181 |
93 |
6 |
Australia |
1195 |
963 |
225 |
7 |
New Zealand |
45 |
37 |
7 |
1 |
Japan |
20 |
15 |
5 |
0 |
Hong Kong |
5 |
5 |
0 |
0 |
South Africa |
10 |
10 |
0 |
0 |
|
|
|
|
|
Overall Total |
3050 |
2352 |
678 |
20 |
Current Totals Submitted To Database |
|||
Normal/Clear |
Carriers |
Affecteds |
Total Listed |
1380 |
341 |
15 |
1736 |
TNS
Pedigrees |
Switzerland |
|
|
|